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Basic Science
Epidemiology
Etilogy: Genetics | Trauma | Cervical Abnormalities/Chiari I | Adverse Early Life Events | Stress | Infection
Pathophysiology: Central Sensitization | Peripheral Tissues | Sleep | Cerebrospinal Fluid Abnormalities | Autonomic Dysfunction | Neuroendocrine Dysfunction | Cytokines
Neuroimaging: Neuroimaging
Basic Science: Epidemiology
Widespread pain and fibromyalgia in a biracial cohort of young women
J Rheumatol. 2007 Apr;34(4):810-7.
Gansky SA, Plesh O...[ view ]
The incidence of fibromyalgia and its associated comorbidities: a population-based retrospective cohort study based on International Classification of Diseases, 9th Revision codes
J Clin Rheumatol. 2006 Jun;12(3):124-8.
Weir PT, Harlan GA, Nkoy FL, Jones SS, Hegmann KT, Gren LH, Lyon JL...[ view ]
Fibromyalgia syndrome in an Amish community: a controlled study to determine disease and symptom prevalence
J Rheumatol. 2003 Aug;30(8):1835-40.
White KP, Thompson J...[ view ]
The London Fibromyalgia Epidemiology Study: the prevalence of fibromyalgia syndrome in London, Ontario
J Rheumatol. 1999 Jul;26(7):1570-6.
White KP, Speechley M, Harth M, Ostbye T...[ view ]
A population study of the incidence of fibromyalgia among women aged 26-55 yr
Br J Rheumatol. 1997 Dec;36(12):1318-23.
Forseth KO, Gran JT, Husby G...[ view ]
The prevalence and characteristics of fibromyalgia in the general population
Arthritis Rheum. 1995 Jan;38(1):19-28.
Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L...[ view ]
Prevalence of primary and secondary fibrositis
J Rheumatol. 1983 Dec;10(6):965-8.
Wolfe F, Cathey MA...[ view ]
Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome
Arthritis Res Ther. 2006;8(5):218.
Buskila D, Sarzi-Puttini P...[ view ]
An internet survey of 2,596 people with fibromyalgia
BMC Musculoskelet Disord. 2007 Mar 98:27.
Bennett RM, Jones J, Turk DC, Russell IJ, Matallana L...[ view ]
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Basic Science: Etiology
Genetics
Family study of fibromyalgia
Arthritis Rheum. 2004 Mar;50(3):944-52.
Arnold LM, Hudson JI, Hess EV, Ware AE, Fritz DA, Auchenbach MB, Starck LO, Keck PE Jr...[ view ]
Quality of life and physical functioning of relatives of fibromyalgia patients
Semin Arthritis Rheum. 1997 Jun;26(6):834-9.
Neumann L, Buskila D...[ view ]
Fibromyalgia syndrome (FM) and nonarticular tenderness in relatives of patients with FM
J Rheumatol. 1997 May;24(5):941-4.
Buskila D, Neumann L...[ view ]
Familial aggregation in the fibromyalgia syndrome
Semin Arthritis Rheum. 1996 Dec;26(3):605-11.
Buskila D, Neumann L, Hazanov I, Carmi R...[ view ]
No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study
BMC Musculoskelet Disord. 2006 May 4;7:40
Hagen K, Pettersen E, Stovner LJ, Skorpen F, Zwart JA... [ view ]
Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome
Rheumatol Int. 2003 May;23(3):104-7.
Gursoy S, Erdal E, Herken H, Madenci E, Alasehirli B, Erdal N...[ view ]
Absence of association of the serotonin transporter gene polymorphism with the mentally healthy subset of fibromyalgia patients.
Clin Rheumatol. 2002 Jun;21(3):194-7.
Gursoy S...[ view ]
An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits
Mol Psychiatry. 2004 Aug;9(8):730-1.
Cohen H, Buskila D, Neumann L, Ebstein RP...[ view ]
Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region.
Arthritis Rheum. 1999 Nov;42(11):2482-8.
Offenbaecher M, Bondy B, de Jonge S, Glatzeder K, Kruger M, Schoeps P, Ackenheil M...[ view ]
The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia
Neurobiol Dis. 1999 Oct;6(5):433-9.
Bondy B, Spaeth M, Offenbaecher M, Glatzeder K, Stratz T, Schwarz M, de Jonge S, Kruger M, Engel RR, Farber L, Pongratz DE, Ackenheil M...[ view ]
Genetic linkage analysis of multicase families with fibromyalgia syndrome
J Rheumatol. 1999 Feb;26(2):408-12.
Yunus MB, Khan MA, Rawlings KK, Green JR, Olson JM, Shah S...[ view ]
Histocompatibility antigens in the fibrositis (Fibromyalgia) syndrome. Clin Exp Rheumatol
Clin Exp Rheumatol. 1986 Oct-Dec;4(4):355-8.
Burda CD, Cox FR, Osborne P...[ view ]
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Trauma
Neck injury and fibromyalgia-- are they really associated
Rheumatol. 2006 Jun;33(6):1183-5.
Tishler M, Levy O, Maslakov I, Bar-Chaim S, Amit-Vazina M. J...[ view ]
The development of persistent pain and psychological morbidity after motor vehicle collision: integrating the potential role of stress response systems into a biopsychosocial model
Psychosom Med. 2005 Sep-Oct;67(5):783-90.
McLean SA, Clauw DJ, Abelson JL, Liberzon I...[ view ]
Fibromyalgia after motor vehicle collision: evidence and implications
Traffic Inj Prev. 2005 Jun;6(2):97-104.
McLean SA, Williams DA, Clauw DJ...[ view ]
Outcome of posttraumatic fibromyalgia: a 3-year follow-up of 78 cases of cervical spine injuries
Semin Arthritis Rheum. 2003 Apr;32(5):320-5.
Neumann L, Zeldets V, Bolotin A, Buskila D...[ view ]
Musculoskeletal injury as a trigger for fibromyalgia/posttraumatic fibromyalgia
Curr Rheumatol Rep. 2000 Apr;2(2):104-8.
Buskila D, Neumann L...[ view ]
Trauma and fibromyalgia: is there an association and what does it mean
Semin Arthritis Rheum. 2000 Feb;29(4):200-16.
White KP, Carette S, Harth M, Teasell RW...[ view ]
Increased rates of fibromyalgia following cervical spine injury. A controlled study of 161 cases of traumatic injury
Arthritis Rheum. 1997 Mar;40(3):446-52.
Buskila D, Neumann L, Vaisberg G, Alkalay D, Wolfe F...[ view ]
Post-traumatic fibromyalgia. A long-term follow-up
Am J Phys Med Rehabil. 1994 Nov-Dec;73(6):403-12
Waylonis GW, Perkins RH...[ view ]
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Cervical Abnormalities/Chiari I
Positional cervical spinal cord compression and fibromyalgia: a novel comorbidity with important diagnostic and treatment implications
J Pain. 2008 Jul;9(7):613-22.
Holman A J...[ view ]
Functional abnormalities of the cervical cord and lower medulla and their effect on pain: observations in chronic pain patients with incidental mild Chiari I malformation and moderate to severe cervical cord compression
Clin J Pain. 2002 May-Jun;18(3):171-9.
Thimineur M, Kitaj M, Kravitz E, Kalizewski T, Sood P...[ view ]
Clinical evidence for cervical myelopathy due to Chiari malformation and spinal stenosis in a non-randomized group of patients with the diagnosis of fibromyalgia
Eur Spine J. 2004 Oct;13(6):516-23.
Heffez DS, Ross RE, Shade-Zeldow Y, Kostas K, Shah S, Gottschalk R, Elias DA, Shepard A, Leurgans SE, Moore CG...[ view ]
Adverse Early Life Events
Childhood trauma and diurnal cortisol disruption in fibromyalgia syndrome
Psychoneuroendocrinology. 2006 Apr;31(3):312-24. Epub 2005 Nov 7.
Weissbecker I, Floyd A, Dedert E, Salmon P, Sephton S...[ view ]
Sexual and physical abuse in women with fibromyalgia syndrome: a test of the trauma hypothesis
Clin J Pain. 2005 Sep-Oct;21(5):378-86.
Ciccone DS, Elliott DK, Chandler HK, Nayak S, Raphael KG...[ view ]
Childhood adversities in patients with fibromyalgia and somatoform pain disorder
Eur J Pain. 2003;7(2):113-9.
Imbierowicz K, Egle UT...[ view ]
Relationship between traumatic events in childhood and chronic pain
Disabil Rehabil. 1999 Jan;21(1):23-30.
Goldberg RT, Pachas WN, Keith D...[ view ]
Sexual and physical abuse in women with fibromyalgia: association with outpatient health care utilization and pain medication usage
Arthritis Care Res. 1998 Apr;11(2):102-15.
Alexander RW, Bradley LA, Alarcon GS, Triana-Alexander M, Aaron LA, Alberts KR, Martin MY, Stewart KE...[ view ]
Psychosocial factors in fibromyalgia compared with rheumatoid arthritis: II. Sexual, physical, and emotional abuse and neglect
Psychosom Med. 1997;59:572577
Walker EA, Keegan D, Gardner G, Sullivan M, Bernstein D, Katon WJ...[ view ]
Sexual and physical abuse in women with fibromyalgia syndrome
Arthritis Rheum. 1995 Feb;38(2):235-41.
Boisset-Pioro MH, Esdaile JM, Fitzcharles MA...[ view ]
The prevalence of sexual abuse in women with fibromyalgia
Arthritis Rheum. 1995 Feb;38(2):229-34.
Taylor ML, Trotter DR, Csuka ME...[ view ]
Hypothalamic-pituitary-adrenal stress axis function and the relationship with chronic widespread pain and its antecedents
Arthritis Res Ther. 2005;7(5):R992-R1000.
McBeth J, Chiu YH, Silman AJ, Ray D, Morriss R, Dickens C, Gupta A, Macfarlane GJ...[ view ]
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Stress
The role of life stress in fibromyalgia
Curr Rheumatol Rep. 2005 Oct;7(5):365-70.
Van Houdenhove B, Egle U, Luyten P...[ view ]
Stress and psychophysiological dysregulation in patients with fibromyalgia syndrome
Appl Psychophysiol Biofeedback. 2002 Jun;27(2):129-41.
Okifuji A, Turk DC...[ view ]
Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link
Arthritis Res Ther. 2004;6(3):98-106. Epub 2004 Apr 7.
Gupta A, Silman AJ...[ view ]
A community-based survey of fibromyalgia-like pain complaints following the World Trade Center terrorist attacks
Pain. 2002 Nov;100(1-2):131-9.
Raphael KG, Natelson BH, Janal MN, Nayak S...[ view ]
Psychosocial factors and the fibromyalgia syndrome
Z Rheumatol. 1998;57 Suppl 2:88-91
Wolfe F, Hawley DJ...[ view ]
Self-reported depression, familial history of depression and fibromyalgia (FM), and psychological distress in patients with FM
Z Rheumatol. 1998;57 Suppl 2:94-6.
Offenbaecher M, Glatzeder K, Ackenheil M...[ view ]
The role of generalized pain and pain behavior in tender point scores in fibromyalgia
J Rheumatol. 2000 Apr;27(4):1056-62.
Nicassio PM, Weisman MH, Schuman C, Young CW...[ view ]
Chronic widespread musculoskeletal pain with or without fibromyalgia: psychological distress in a representative community adult sample
J Rheumatol. 2002 Mar;29(3):588-94.
White KP, Nielson WR, Harth M, Ostbye T, Speechley M...[ view ]
Perceived physical and emotional trauma as precipitating events in fibromyalgia. Associations with health care seeking and disability status but not pain severity
Arthritis Rheum. 1997 Mar;40(3):453-60.
Aaron LA, Bradley LA, Alarcón GS, Triana-Alexander M, Alexander RW, Martin MY, Alberts KR...[ view ]
Prevalence of post-traumatic stress disorder in fibromyalgia patients: overlapping syndromes or post-traumatic fibromyalgia syndrome
Semin Arthritis Rheum. 2002 Aug;32(1):38-50.
Cohen H, Neumann L, Haiman Y, Matar MA, Press J, Buskila D...[ view ]
In the face of pain: the relationship between psychological well-being and disability in women with fibromyalgia
Psychother Psychosom. 2005;74(4):231-9.
Schleicher H, Alonso C, Shirtcliff EA, Muller D, Loevinger BL, Coe CL...[ view ]
Persistent pain and depression: a biopsychosocial perspective
Biol Psychiatry. 2003 Aug 1;54(3):399-409.
Campbell LC, Clauw DJ, Keefe FJ...[ view ]
The role of catastrophizing in the pain and depression of women with fibromyalgia syndrome
Arthritis Rheum. 2000 Nov;43(11):2493-500.
Hassett AL, Cone JD, Patella SJ, Sigal LH...[ view ]
The role of work stress as a moderating variable in the chronic pain and depression association
J Psychosom Res. 2006 Nov;61(5):653-60.
Munce SE, Weller I, Robertson Blackmore EK, Heinmaa M, Katz J, Stewart DE...[ view ]
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Infection
Fibromyalgia frequency in hepatitis B carriers
J Clin Rheumatol. 2005 Jun;11(3):157-9.
Adak B, Tekeoğlu I, Ediz L, Budancamanak M, Yazgan T, Karahocagil K, Demirel A...[ view ]
Higher prevalence of fibromyalgia in patients infected with human T cell lymphotropic virus type I
J Rheumatol. 2006 Nov;33(11):2300-3.
Cruz BA, Catalan-Soares B, Proietti F...[ view ]
Fibromyalgia, hepatitis C infection, and the cytokine connection
Curr Pain Headache Rep. 2003 Oct;7(5):342-7.
Thompson ME, Barkhuizen A...[ view ]
Lack of association of fibromyalgia with hepatitis C virus infection
J Rheumatol. 2005 Jun;32(6):1118-21.
Narváez J, Nolla JM, Valverde-García J...[ view ]
A prospective study of tender points and fibromyalgia during and after an acute viral infection
Arch Intern Med. 1999 Apr 26; 159(8):865-70.
Rea T, Russo J, Katon W, Ashley RL, Buchwald D...[ view ]
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Basic Science: Pathophysiology
Central Sensitization
A psychophysical study of auditory and pressure sensitivity in patients with fibromyalgia and healthy controls
J Pain. 2008 May;9(5):417-22.
Geisser ME , Glass JM, Rajcevska LD , Clauw D J, Williams DA , Kileny PR, Gracely RH...[ view ]
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Peripheral Tissues
A subset of fibromyalgia patients have findings suggestive of chronic inflammatory demyelinating polyneuropathy and appear to respond to IVIg
Rheumatology (Oxford). 2008 Feb;47(2):208-11.
Caro X J, Winter EF , Dumas A J... [ view ]
Overall fibromyalgia pain is predicted by ratings of local pain and pain-related negative affect—possible role of peripheral tissues
Rheumatology (Oxford). 2006 Nov;45(11):1409-15.
Staud R , Vierck CJ, Robinson ME , Price DD... [ view ]
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Sleep
The significance of the sleeping-waking brain for the understanding of widespread musculoskeletal pain and fatigue in fibromyalgia syndrome and allied syndromes
Joint Bone S pine. 2008 Jul;75(4):397-402.
Moldofsky, H...[ view ]
Musculosketal symptoms and non-REMsleep disturbance in patients with “fibrositis syndrome” and healthy subjects
Psychosom Med. 1975 Jul-Aug;37(4):341-51.
Moldofsky H, Scarisbrick P, England R, Smythe H...[ view ]
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Cerebrospinal Fluid Abnormalities
Cerebrospinal fluid corticotropin-releasing factor concentration is associated with pain but not fatigue symptoms in patients
Neuropsychopharmacology. 2006 Dec;31(12):2776-82. Epub 2006 Aug 23.
McLean SA, Williams DA, Stein PK, Harris RE, Lyden AK, Whalen G, Park KM, Liberzon I, Sen A, Gracely RH, Baraniuk JN, Clauw DJ...[ view ]
Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome
Arthritis Rheum. 1994 Nov;37(11):1593-601.
Russell IJ, Orr MD, Littman B, Vipraio GA, Alboukrek D, Michalek JE, Lopez Y, MacKillip F...[ view ]
Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis
Arthritis Rheum. 1992 May;35(5):550-6.
Russell IJ, Vaeroy H, Javors M, Nyberg F...[ view ]
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Autonomic Dysfunction
Autonomic activation and pain in response to low-grade mental stress in fibromyalgia and shoulder/neck pain patients
Eur J Pain. 2007 Oct;11(7):743-55.
Nilsen KB , S and T, W estgaard RH , Stovner L J, White LR , Bang Leistad R, Helde G, RøM...[ view ]
Circadian studies of autonomic nervous balance in patients with fibromyalgia: a heart rate variability analysis
Arthritis Rheum. 1998 Nov;41(11):1966-71.
Martínez-Lavin M, Hermosillo AG, Rosas M, Soto ME...[ view ]
Abnormalities of cardiovascular neural control and reduced orthostatic tolerance in patients with primary fibromyalgia
J Rheumatol. 2005 Sep;32(9):1787-93.
Furlan R, Colombo S, Perego F, Atzeni F, Diana A, Barbic F, Porta A, Pace F, Malliani A, Sarzi-Puttini P...[ view ]
Dysautonomia in fibromyalgia syndrome: sympathetic skin responses and RRInterval analysis
Rheumatol Int. 2006 Mar;26(5):383-7.
Ulas UH, Unlu E, Hamamcioglu K, Odabasi Z, Cakci A, Vural O...[ view ]
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Neuroendocrine Dysfunction
Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones
Z Rheumatol. 1998;57 Suppl 2:81-7. Riedel W, Layka H, Neeck G...[ view ]
Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome
Rheum Dis Clin North Am. 2000 Nov;26(4):989-1002.
Neeck G, Crofford LJ...[ view ]
Growth hormone perturbations in fibromyalgia: a review
Semin Arthritis Rheum. 2007 Jun;36(6):357-79.
Jones KD, Deodhar P, Lorentzen A, Bennett RM, Deodhar AA...[ view ]
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Cytokines
Cytokine patterns in fibromyalgia and their correlation with clinical manifestations
Clin Exp Rheumatol. 2007 Mar-Apr;25(2):225-30.
Bazzichi L , Rossi A , Massimetti G , Giannaccini G , Giuliano T, De Feo F, Ciapparelli A , Dell’Osso L , Bombardieri S...[ view ]
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Basic Science: Neuroimaging
Neuroimaging
Working memory performance is correlated with local brain morphology in the medial frontal and anterior cingulate cortex in fibromyalgia patients: structural correlates of pain-cognition interaction
Brain. 2008 Sep 26.
Luerding R, Weigand T, Bogdahn U, Schmidt-Wilcke T...[ view ]
Hippocampus dysfunction may explain symptoms of fibromyalgia syndrome. A study with single-voxel magnetic resonance spectroscopy
J Rheumatol. 2008 Jul;35(7):1371-7.
Emad Y , Ragab Y , Zeinhom F , E l-Khouly G ,Abou-Zeid A , Rasker JJ...[ view ]
Proton MR spectroscopy in the evaluation of cerebral metabolism in patients with fibromyalgia: comparison with healthy controls and correlation with symptom severity
AJNRA m J Neuroradiol. 2008 May;29(5):913-8.
Petrou M , Harris RE , Foerster BR , McLean SA , Sen A ,Clauw DJ, Sundgren PC...[ view ]
Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia
Arthritis Rheum. 2008 Mar;58(3):903-7.
Harris RE , Sundgren PC, Pang Y , Hsu M , Petrou M ,Kim SH , McLean SA , Gracely RH , Clauw D J...[ view ]
Striatal grey matter increase in patients suffering from fibromyalgia—a voxelbased morphometry study
Pain. 2007 Nov; 132 Suppl 1:S109-16.
Schmidt-Wilcke T, Luerding R , Weigand T, Jürgens T, Schuierer G , Leinisch E , Bogdahn U...[ view ]
The effects of multidisciplinary therapy on positron emission tomography of the brain in fibromyalgia: a pilot study
Rheumatol Int. 2007 Sep; 27(11):1019-24.
Walitt B , Roebuck-Spencer T, Esposito G , Atkins F , Bleiberg J, Foster G , Weinstein A...[ view ]
Decreased central muopioid receptor availability in fibromyalgia
J Neurosci. 2007 Sep 12;27(37):10000-6.
Harris RE , Clauw D J, Scott D J, McLean SA , Gracely RH , Zubieta JK...[ view ]
Fibromyalgia in women Abnormalities of regional cerebral blood flow in the thalamus and the caudate nucleus are associated with low pain threshold levels
Arthritis Rheum. 1995 Jul;38(7):926-38.
Mountz JM, Bradley LA, Modell JG, Alexander RW, Triana-Alexander M, Aaron LA, Stewart KE, Alarcon GS, Mountz JD...[ view ]
Regional cerebral blood flow in fibromyalgia: single-photon-emission computed tomography evidence of reduction in the pontine tegmentum and thalami
Arthritis Rheum. 2000 Dec;43(12):2823-33.
Kwiatek R, Barnden L, Tedman R, Jarrett R, Chew J, Rowe C, Pile K...[ view ]
(99m)Tc-ECD brain perfusion SPECT in hyperalgesic fibromyalgia
Eur J Nucl Med Mol Imaging. 2007 Jan;34(1):130-4.
Guedj E, Taieb D, Cammilleri S, Lussato D, de Laforte C, Niboyet J, Mundler O...[ view ]
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia
Arthritis Rheum. 2002 May;46(5):1333-43.
Gracely RH, Petzke F, Wolf JM, Clauw DJ...[ view ]
Functional imaging of pain in patients with primary fibromyalgia
J Rheumatol. 2004 Feb;31(2):364-78.
Cook DB, Lange G, Ciccone DS, Liu WC, Steffener J, Natelson BH...[ view ]
Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain
J Neurosci. 2007 Apr 11;27(15):4004-7.
Kuchinad A, Schweinhardt P, Seminowicz DA, Wood PB, Chizh BA, Bushnell MC...[ view ]
Reduced presynaptic dopamine activity in fibromyalgia syndrome demonstrated with positron emission tomography: a pilot study
J Pain. 2007 Jan;8(1):51-8.
Wood PB, Patterson JC 2nd, Sunderland JJ, Tainter KH, Glabus MF, Lilien DL...[ view ]
Fibromyalgia patients show an abnormal dopamine response to pain
Eur J Neurosci. 2007 Jun;25(12):3576-82.
Wood PB, Schweinhardt P, Jaeger E, Dagher A, Hakyemez H, Rabiner EA, Bushnell MC, Chizh BA...[ view ]
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