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Treatment
RX, Controlled Data
Pregabalin | Duloxetine | Milnacipran | Pramipexole | Sodium Oxybate
Gabapentin
Tramadol | Fluoxetine/Amitriptyline | Cyclobenzaprine | Growth Hormone/Pyridostigmine | Synthetic Cannaboids
RX, Uncontrolled Data
Pindolol | Venlafaxine
Over-theCounter (OTC) Medications
Acetyl L-Carnitine | Melatonin
Complementary and Alternative Medicine (CAM) Therapies
Cranial Electrotherapy | Heart Rate Variability | Biofeedback | Exercise
Treatment: RX, Controlled Data
Pregabalin
Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREE DOM ): a 6-month, doubleblind, placebo-controlled trial with pregabalin
Pain. 2008 Jun;136(3):419-31.
Crofford L J, Mease PJ, S impson SL , Young JP Jr, Martin SA , Haig GM , Sharma U...[ view ]
A 14-week, Randomized, Double-Blinded, Placebo-Controlled Monotherapy Trial of Pregabalin in Patients With Fibromyalgia
J Pain. 2008 Sept; 9(9): 792-805. Arnold LM, Russell IJ, Diri EW, Duan WR, Young, Jr JP, Sharma U, Martin SA, Barrett JA, Haig G...[ view ]
Duloxetine
Efficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: Results from a 6-month, randomized, double-blind, placebo-controlled, fixed-dose trial
Pain. 2008 Jun;136(3):432-44. Russell I J, Mease PJ, Smith TR, Kajdasz DK ,Wohlreich MM , Detke M J, Walker D J, Chappell AS , Arnold LM...[ view ]
A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder
Pain. 2005 Dec 15;119(1-3):5-15. Arnold LM, Rosen A, Pritchett YL, D’Souza DN, Goldstein DJ, Iyengar S, Wernicke JF...[ view ]
A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder
Arthritis Rheum. 2004 Sep;50(9):2974-84. Arnold LM, Lu Y, Crofford LJ, Wohlreich M, Detke MJ, Iyengar S, Goldstein DJ...[ view ]
Milnacipran
Efficacy of milnacipran in patients with fibromyalgia
J Rheumatol. 2005 Oct;32(10):1975-85. Gendreau RM, Thorn MD, Gendreau JF, Kranzler JD, Ribeiro S, Gracely RH, Williams DA, Mease PJ, McLean SA, Clauw DJ...[ view ]
Pramipexole
A randomized, double-blind, placebo-controlled trial of pramipexole, a dopamine agonist, in patients with fibromyalgia receiving concomitant medications
Arthritis Rheum. 2005 Aug;52(8):2495-505.
Holman AJ, Myers RR...[ view ]
Safety and efficacy of the dopamine agonist, pramipexole, on pain score for refractory fibromyalgia
Arthritis Rheum 2000;43 Suppl:A1599.
Holman AJ...[ view ]
Sodium Oxybate
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Trial Comparing the Effects of Orally Administered Xyrem® (Sodium Oxybate) with Placebo for the Treatment of Fibromyalgia
Pain Medicine. 2006; 7(2):170209. Wood PB...[ view ]
The effects of sodium oxybate on clinical symptoms and sleep patterns in patients with fibromyalgia
J Rheumatol. 2003 May;30(5):1070-4. Scharf MB, Baumann M, Berkowitz DV...[ view ]
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Treatment: Gabapentin
Gabapentin in the treatment of fibromyalgia: a randomized, double-blind, placebo-controlled, multicenter trial
Arthritis Rheum. 2007 Apr;56(4):1336-44. Arnold LM, Goldenberg DL, Stanford SB, Lalonde JK, Sandhu HS, Keck PE Jr, Welge JA, Bishop F, Stanford KE, Hess EV, Hudson JI. ..[ view ]
Fluoxetine/ Amitriptyline
A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia
Arthritis Rheum. 1996 Nov;39(11):1852-9. Goldenberg D, Mayskiy M, Mossey C, Ruthazer R, Schmid C...[ view ]
Cyclobenzaprine
Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis
Arthritis Rheum. 2004 Feb 15;51(1):9-13. Tofferi JK, Jackson JL, O’Malley PG...[ view ]
Growth Hormone/Pyridostigmine
A randomized, double-blind, placebo-controlled study of growth hormone in the treatment of fibromyalgia
Am J Med. 1998 Mar;104(3):227-31. Bennett RM, Clark SC, Walczyk J...[ view ]
A combination of 6 months of treatment with pyridostigmine and triweekly exercise fails to improve insulin-like growth factor-Ilevels in fibromyalgia, despite improvement in the acute growth hormone response to exercise
J Rheumatol. 2007 May;34(5):1103-11. Jones KD, Deodhar AA, Burckhardt CS, Perrin NA, Hanson GC, Bennett RM...[ view ]
Synthetic Cannaboids
Nabilone for the treatment of pain in fibromyalgia
J Pain. 2008 Feb;9(2):164-73. Skrabek R Q, Galimova L , Ethans K , Perry D...[ view ]
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Treatment: RX, Uncontrolled Data
Pindolol
Open trial of pindolol in the treatment of fibromyalgia
Ann Pharmacother. 2005 Nov;39(11):1812-6.
Wood PB, Kablinger AS, Caldito GS...[ view ]
Venlafaxine
Venlafaxine treatment of fibromyalgia
Ann Pharmacother. 2003 Nov;37(11):1561-5. Sayar K, Aksu G, Ak I, Tosun M...[ view ]
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Treatment: Over-theCounter (OTC) Medications
Alcar
Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients
Clin Exp Rheumatol. 2007 Mar-Apr;25(2):182-8. Rossini M, Di Munno O, Valentini G, Bianchi G, Biasi G, Cacace E, Malesci D, La Montagna G, Viapiana O, Adami S...[ view ]
Melatonin
The effect of melatonin in patients with fibromyalgia: a pilot study
Clin Rheumatol. 2000;19(1):9-13. Citera G, Arias MA, Maldonado-Cocco JA, Lázaro MA, Rosemffet MG, Brusco LI, Scheines EJ, Cardinalli DP...[ view ]
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Treatment: Complementary and Alternative Medicine (CAM) Therapies
Treatment of cervical myelopathy in patients with the fibromyalgia syndrome: outcomes and implications
Eur Spine J. 2007 Apr 11. Heffez DS, Ross RE, Shade-Zeldow Y, Kostas K, Morrissey M, Elias DA, Shepard A...[ view ]
Cranial Electrotherapy Stimulation
The treatment of fibromyalgia with cranial electrotherapy stimulation
J Clin Rheumatol. 2001 Apr;7(2):72-8. Lichtbroun AS, Raicer MM, Smith RB...[ view ]
The Effect of Cranial Electrotherapy Stimulation (CES) on Pain Associated with Fibromyalgia
The Internet Journal of Anesthesiology. 2004; 8(2). Cork RC, Wood PB, Ming N, Shepherd C, Eddy J, Price L...[ view ]
Heart Rate Variability
A pilot study of the efficacy of heart rate variability (HRV) biofeedback in patients with fibromyalgia
Appl Psychophysiol Biofeedback. 2007 Mar;32(1):1-10. Hassett AL , Radvanski D C, Vaschillo EG , Vaschillo B ,Sigal LH , Karavidas MK , Buyske S , Lehrer PM...[ view ]
Exercise
Self-assessed physical function levels of women with fibromyalgia: a national survey
Arthritis Res Ther. 2008 Aug 8;10(4):211. Jones J, Rutledge DN, Jones KD, Matallana L, Rooks DS...[ view ]
Exercise-based motivational interviewing for female patients with fibromyalgia: a case series
Clin Rheumatol. 2007 N ov;26(11):1843-9. Ang D , Kesavalu R , Lydon JR, Lane KA , Bigatti S...[ view ]
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